Phenyl Butyl Nitrone Compositions and Methods for Treatment of Oxidative Tissue Damage
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Original Contribution OXIDATIVE STRESS IN BRAIN DURING EXPERIMENTAL BACTERIAL MENINGITIS: DIFFERENTIAL EFFECTS OF a-PHENYL-TERT-BUTYL NITRONE AND N-ACETYLCYSTEINE TREATMENT
Antioxidant treatment has previously been shown to be neuroprotective in experimental bacterial meningitis. To obtain quantitative evidence for oxidative stress in this disease, we measured the major brain antioxidants ascorbate and reduced glutathione, and the lipid peroxidation endproduct malondialdehyde in the cortex of infant rats infected with Streptococcus pneumoniae. Cortical levels of t...
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متن کاملFirst Synthesis of C-Phenyl N-tert-Buty\ [15N]nitrone (PBN-15N) for the EPR Spin Trapping Methodology
C-Phenyl N-tert-Butyl [15N]nitrone, Nitrone, Spin Trap, EPR Spin Trapping, Aminoxyl (Nitroxide) As compared to normal PBN, about fifty percent increase of electron paramagnetic reso nance (EPR) spin trapping sensitivity has been gained by using a new 100% 1:>N-enriched spin trap, C-phenyl /V-rm-butyl[15N]nitrone (PBN-15N). PBN-15N has been prepared by a convenient four-step route using ammoniu...
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